Impact of CFTR Modulation on Intestinal pH, Motility, and Clinical Outcomes in Patients With Cystic Fibrosis and the G551D Mutation

OBJECTIVES: A defect in bicarbonate secretion contributes to the pathophysiology of gastrointestinal complications in patients with cystic fibrosis (CF). We measured gastrointestinal pH, clinical outcomes, and intestinal transit profiles in patients with the G551D mutation before and after treatment...

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Detalles Bibliográficos
Autores principales: Gelfond, Daniel, Heltshe, Sonya, Ma, Changxing, Rowe, Steven M, Frederick, Carla, Uluer, Ahmet, Sicilian, Leonard, Konstan, Michael, Tullis, Elizabeth, Roach, R N Christine, Griffin, Katherine, Joseloff, Elizabeth, Borowitz, Drucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387753/
https://www.ncbi.nlm.nih.gov/pubmed/28300821
http://dx.doi.org/10.1038/ctg.2017.10

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