Cargando…

Role of Protein Kinase C and Nox2-Derived Reactive Oxygen Species Formation in the Activation and Maturation of Dendritic Cells by Phorbol Ester and Lipopolysaccharide

Aims. Activation/maturation of dendritic cells (DCs) plays a central role in adaptive immune responses by antigen processing and (cross-) activation of T cells. There is ongoing discussion on the role of reactive oxygen species (ROS) in these processes and with the present study we investigated this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stein, Judith, Steven, Sebastian, Bros, Matthias, Sudowe, Stephan, Hausding, Michael, Oelze, Matthias, Münzel, Thomas, Grabbe, Stephan, Reske-Kunz, Angelika, Daiber, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387830/ https://www.ncbi.nlm.nih.gov/pubmed/28458776 http://dx.doi.org/10.1155/2017/4157213

Ejemplares similares

Geldanamycin-mediated inhibition of heat shock protein 90 partially activates dendritic cells, but interferes with their full maturation, accompanied by impaired upregulation of RelB
por: Trojandt, Stefanie, et al.
Publicado: (2014)

Inhibition of experimental autoimmune encephalomyelitis by tolerance-promoting DNA vaccination focused to dendritic cells
por: Castor, Timo, et al.
Publicado: (2018)

Friend virus limits adaptive cellular immune responses by imprinting a maturation-resistant and T helper type 2-biased immunophenotype in dendritic cells
por: Shen, Limei, et al.
Publicado: (2018)

Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?
por: Hieber, Christoph, et al.
Publicado: (2023)

NOX2ko Mice Show Largely Increased Expression of a Mutated NOX2 mRNA Encoding an Inactive NOX2 Protein
por: Göllner, Monika, et al.
Publicado: (2020)

NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy
por: Brandt, Moritz, et al.
Publicado: (2016)

Regulation of urokinase receptors in monocytelike U937 cells by phorbol ester phorbol myristate acetate
Publicado: (1989)

Interleukin-1 Beta—A Friend or Foe in Malignancies?
por: Bent, Rebekka, et al.
Publicado: (2018)

RhoA as a Key Regulator of Innate and Adaptive Immunity
por: Bros, Matthias, et al.
Publicado: (2019)

β2 Integrins—Multi-Functional Leukocyte Receptors in Health and Disease
por: Bednarczyk, Monika, et al.
Publicado: (2020)

The Functional Crosstalk between Myeloid-Derived Suppressor Cells and Regulatory T Cells within the Immunosuppressive Tumor Microenvironment
por: Haist, Maximilian, et al.
Publicado: (2021)

Inhibitors of the Actin-Bundling Protein Fascin-1 Developed for Tumor Therapy Attenuate the T-Cell Stimulatory Properties of Dendritic Cells
por: Zeyn, Yanira, et al.
Publicado: (2022)

E-cigarette effects on vascular function in animals and humans
por: Daiber, Andreas, et al.
Publicado: (2023)

BRAF inhibitors stimulate inflammasome activation and interleukin 1 beta production in dendritic cells
por: Hajek, Eva, et al.
Publicado: (2018)

The Endothelin Receptor Antagonist Macitentan Improves Isosorbide-5-Mononitrate (ISMN) and Isosorbide Dinitrate (ISDN) Induced Endothelial Dysfunction, Oxidative Stress, and Vascular Inflammation
por: Steven, Sebastian, et al.
Publicado: (2018)

Antiallergic Phorbol Ester from the Seeds of Aquilaria malaccensis
por: Korinek, Michal, et al.
Publicado: (2016)

Taking up the cudgels for the traditional reactive oxygen and nitrogen species detection assays and their use in the cardiovascular system
por: Daiber, Andreas, et al.
Publicado: (2017)

Cell surface dynamics of neutrophils stimulated with phorbol esters or retinoids
Publicado: (1987)

Immunomodulatory Properties of BRAF and MEK Inhibitors Used for Melanoma Therapy—Paradoxical ERK Activation and Beyond
por: Jung, Thomas, et al.
Publicado: (2021)

Immunomodulatory Properties of Immune Checkpoint Inhibitors—More than Boosting T-Cell Responses?
por: Kuske, Michael, et al.
Publicado: (2022)

THE TUMOR-PROMOTER PHORBOL ESTER (12-0-TETRADECANOYL-PHORBOL-13-ACETATE), A POTENT AGGREGATING AGENT FOR BLOOD PLATELETS
por: Zucker, Marjorie B., et al.
Publicado: (1974)

Regulation of agrin-induced acetylcholine receptor aggregation by Ca++ and phorbol ester
Publicado: (1988)

Phorbol ester degradation in Jatropha seedcake using white rot fungi
por: Bose, Anjali, et al.
Publicado: (2013)

Vascular Dysfunction in Experimental Diabetes Is Improved by Pentaerithrityl Tetranitrate but Not Isosorbide-5-Mononitrate Therapy
por: Schuhmacher, Swenja, et al.
Publicado: (2011)

Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats
por: Stamm, P, et al.
Publicado: (2015)

The Role of LFA-1 for the Differentiation and Function of Regulatory T Cells—Lessons Learned from Different Transgenic Mouse Models
por: Klaus, Tanja, et al.
Publicado: (2023)

Oxidative Stress in Cardiac Tissue of Patients Undergoing Coronary Artery Bypass Graft Surgery: The Effects of Overweight and Obesity
por: Gramlich, Yves, et al.
Publicado: (2018)

Phorbol ester-induced actin assembly in neutrophils: role of protein kinase C
Publicado: (1992)

Phorbol esters alter cell fate during development of sea urchin embryos
Publicado: (1992)

Phorbol ester modulation of integrin-mediated cell adhesion: a postreceptor event
Publicado: (1989)

Reorganization of alpha-actinin and vinculin induced by a phorbol ester in living cells
Publicado: (1986)

Phorbol ester induces elevated oxidative activity and alkalization in a subset of lysosomes
por: Chen, Chii-Shiarng
Publicado: (2002)

Organic Nitrates and Nitrate Resistance in Diabetes: The Role of Vascular Dysfunction and Oxidative Stress with Emphasis on Antioxidant Properties of Pentaerithrityl Tetranitrate
por: Oelze, Matthias, et al.
Publicado: (2010)

Mechanisms by Which Licochalcone E Exhibits Potent Anti-Inflammatory Properties: Studies with Phorbol Ester-Treated Mouse Skin and Lipopolysaccharide-Stimulated Murine Macrophages
por: Lee, Han Na, et al.
Publicado: (2013)

A Trifunctional Dextran-Based Nanovaccine Targets and Activates Murine Dendritic Cells, and Induces Potent Cellular and Humoral Immune Responses In Vivo
por: Shen, Limei, et al.
Publicado: (2013)

CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis
por: Teschner, Daniel, et al.
Publicado: (2019)

Regulation of Vascular Function and Inflammation via Cross Talk of Reactive Oxygen and Nitrogen Species from Mitochondria or NADPH Oxidase—Implications for Diabetes Progression
por: Daiber, Andreas, et al.
Publicado: (2020)

The Protein Corona as a Confounding Variable of Nanoparticle-Mediated Targeted Vaccine Delivery
por: Bros, Matthias, et al.
Publicado: (2018)

Combination of immune-checkpoint inhibitors and targeted therapies for melanoma therapy: The more, the better?
por: Haist, Maximilian, et al.
Publicado: (2023)

The Sodium-Glucose Co-Transporter 2 Inhibitor Empagliflozin Improves Diabetes-Induced Vascular Dysfunction in the Streptozotocin Diabetes Rat Model by Interfering with Oxidative Stress and Glucotoxicity
por: Oelze, Matthias, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_5412c73j9q5t1bf21dns8cdpq5