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Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat

Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) technology, is well-established. Conducting long-term toxicity studies in animals using human proteins can be complicated by...

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Detalles Bibliográficos
Autores principales:	Rasmussen, Caroline E., Nowak, Jette, Larsen, Julie M., Moore, Emma, Bell, David, Liu, Kai Chiu, Sorensen, Nanna Skall, Kappers, Wendela A., Krogh-Meibom, Thomas, Offenberg, Hanne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5387834/ https://www.ncbi.nlm.nih.gov/pubmed/28458688 http://dx.doi.org/10.1155/2017/8496246

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