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Association of the genetic markers for myocardial infarction with sudden cardiac death

OBJECTIVE: Investigate the association of rs17465637 gene MIAF3 (1q41), rs1376251 gene TAS2R50 (12p13), rs4804611 gene ZNF627 (19p13), rs619203 gene ROS1 (6q22), rs1333049 (9p21), rs10757278 (9p21), rs2549513 (16q23), rs499818 (6p24) associated with myocardial infarction available from the internati...

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Autores principales: Ivanova, Anastasiya A., Maksimov, Vladimir N., Orlov, Pavel S., Ivanoshchuk, Dinara E., Savchenko, Sergei V., Voevoda, Mikhail I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388015/
https://www.ncbi.nlm.nih.gov/pubmed/28400043
http://dx.doi.org/10.1016/j.ihj.2016.07.016
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author Ivanova, Anastasiya A.
Maksimov, Vladimir N.
Orlov, Pavel S.
Ivanoshchuk, Dinara E.
Savchenko, Sergei V.
Voevoda, Mikhail I.
author_facet Ivanova, Anastasiya A.
Maksimov, Vladimir N.
Orlov, Pavel S.
Ivanoshchuk, Dinara E.
Savchenko, Sergei V.
Voevoda, Mikhail I.
author_sort Ivanova, Anastasiya A.
collection PubMed
description OBJECTIVE: Investigate the association of rs17465637 gene MIAF3 (1q41), rs1376251 gene TAS2R50 (12p13), rs4804611 gene ZNF627 (19p13), rs619203 gene ROS1 (6q22), rs1333049 (9p21), rs10757278 (9p21), rs2549513 (16q23), rs499818 (6p24) associated with myocardial infarction available from the international genome-wide studies with sudden cardiac death (SCD) in a case–control study. METHODS: A sample of SCD cases (n = 285) was formed using the WHO criteria; the control sample (n = 421) was selected according to sex and age. DNA was isolated by phenol–chloroform extraction from the myocardial tissue of SCD cases and blood of control cases. The groups were genotyped for the selected SNPs by real-time PCR using TaqMan probes (Applied Biosystems, United States). RESULTS: No statistically significant differences in the genotype and allelic frequencies of studied single nucleotide polymorphisms between sudden cardiac death cases and control were detectable in general group. By separating the groups of sex and age differences in the genotype frequencies of rs1333049, rs10757278 and rs499818 are statistical significance. Genotypes CC of rs1333049 and GG of rs10757278 are associated with an increased sudden cardiac death risk in men (p = 0.019, OR = 1.7, 95% CI 1.1–2.8; p = 0.011, OR = 1.8, 95% CI 1.2–2.8, respectively). Genotype AG of rs499818 is associated with an increased sudden cardiac death risk in the women over 50 years old (p = 0.009, OR = 2.4, 95% CI 1.3–4.6). CONCLUSION: Polymorphisms rs1333049 and rs10757278 are associated with SCD in men and rs499818 in the women aged over 50 years.
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spelling pubmed-53880152018-04-01 Association of the genetic markers for myocardial infarction with sudden cardiac death Ivanova, Anastasiya A. Maksimov, Vladimir N. Orlov, Pavel S. Ivanoshchuk, Dinara E. Savchenko, Sergei V. Voevoda, Mikhail I. Indian Heart J Original Article OBJECTIVE: Investigate the association of rs17465637 gene MIAF3 (1q41), rs1376251 gene TAS2R50 (12p13), rs4804611 gene ZNF627 (19p13), rs619203 gene ROS1 (6q22), rs1333049 (9p21), rs10757278 (9p21), rs2549513 (16q23), rs499818 (6p24) associated with myocardial infarction available from the international genome-wide studies with sudden cardiac death (SCD) in a case–control study. METHODS: A sample of SCD cases (n = 285) was formed using the WHO criteria; the control sample (n = 421) was selected according to sex and age. DNA was isolated by phenol–chloroform extraction from the myocardial tissue of SCD cases and blood of control cases. The groups were genotyped for the selected SNPs by real-time PCR using TaqMan probes (Applied Biosystems, United States). RESULTS: No statistically significant differences in the genotype and allelic frequencies of studied single nucleotide polymorphisms between sudden cardiac death cases and control were detectable in general group. By separating the groups of sex and age differences in the genotype frequencies of rs1333049, rs10757278 and rs499818 are statistical significance. Genotypes CC of rs1333049 and GG of rs10757278 are associated with an increased sudden cardiac death risk in men (p = 0.019, OR = 1.7, 95% CI 1.1–2.8; p = 0.011, OR = 1.8, 95% CI 1.2–2.8, respectively). Genotype AG of rs499818 is associated with an increased sudden cardiac death risk in the women over 50 years old (p = 0.009, OR = 2.4, 95% CI 1.3–4.6). CONCLUSION: Polymorphisms rs1333049 and rs10757278 are associated with SCD in men and rs499818 in the women aged over 50 years. Elsevier 2017-04 2016-07-30 /pmc/articles/PMC5388015/ /pubmed/28400043 http://dx.doi.org/10.1016/j.ihj.2016.07.016 Text en © 2016 Published by Elsevier B.V. on behalf of Cardiological Society of India. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Ivanova, Anastasiya A.
Maksimov, Vladimir N.
Orlov, Pavel S.
Ivanoshchuk, Dinara E.
Savchenko, Sergei V.
Voevoda, Mikhail I.
Association of the genetic markers for myocardial infarction with sudden cardiac death
title Association of the genetic markers for myocardial infarction with sudden cardiac death
title_full Association of the genetic markers for myocardial infarction with sudden cardiac death
title_fullStr Association of the genetic markers for myocardial infarction with sudden cardiac death
title_full_unstemmed Association of the genetic markers for myocardial infarction with sudden cardiac death
title_short Association of the genetic markers for myocardial infarction with sudden cardiac death
title_sort association of the genetic markers for myocardial infarction with sudden cardiac death
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388015/
https://www.ncbi.nlm.nih.gov/pubmed/28400043
http://dx.doi.org/10.1016/j.ihj.2016.07.016
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