Current Status of Dengue Therapeutics Research and Development

Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral target...

Descripción completa

Detalles Bibliográficos
Autores principales: Low, Jenny G. H., Ooi, Eng Eong, Vasudevan, Subhash G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Supplement Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388029/
https://www.ncbi.nlm.nih.gov/pubmed/28403438
http://dx.doi.org/10.1093/infdis/jiw423
_version_ 1782521056047661056
author Low, Jenny G. H.
Ooi, Eng Eong
Vasudevan, Subhash G.
author_facet Low, Jenny G. H.
Ooi, Eng Eong
Vasudevan, Subhash G.
author_sort Low, Jenny G. H.
collection PubMed
description Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. This review will provide a brief account of the status of therapeutics research and development for dengue.
format Online
Article
Text
id pubmed-5388029
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-53880292017-04-24 Current Status of Dengue Therapeutics Research and Development Low, Jenny G. H. Ooi, Eng Eong Vasudevan, Subhash G. J Infect Dis Supplement Article Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. This review will provide a brief account of the status of therapeutics research and development for dengue. Oxford University Press 2017-03-01 2017-02-04 /pmc/articles/PMC5388029/ /pubmed/28403438 http://dx.doi.org/10.1093/infdis/jiw423 Text en © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, contact journals.permissions@oup.com.
spellingShingle Supplement Article
Low, Jenny G. H.
Ooi, Eng Eong
Vasudevan, Subhash G.
Current Status of Dengue Therapeutics Research and Development
title Current Status of Dengue Therapeutics Research and Development
title_full Current Status of Dengue Therapeutics Research and Development
title_fullStr Current Status of Dengue Therapeutics Research and Development
title_full_unstemmed Current Status of Dengue Therapeutics Research and Development
title_short Current Status of Dengue Therapeutics Research and Development
title_sort current status of dengue therapeutics research and development
topic Supplement Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388029/
https://www.ncbi.nlm.nih.gov/pubmed/28403438
http://dx.doi.org/10.1093/infdis/jiw423
work_keys_str_mv AT lowjennygh currentstatusofdenguetherapeuticsresearchanddevelopment
AT ooiengeong currentstatusofdenguetherapeuticsresearchanddevelopment
AT vasudevansubhashg currentstatusofdenguetherapeuticsresearchanddevelopment

Ejemplares similares