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Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016

In eastern Europe, few countries have so far reported laboratory-confirmed cases of lymphogranuloma venereum (LGV). Here we describe 22 LGV cases in men who have sex with men (MSM) detected in Hungary from November 2012 to July 2016. Sequence analyses show that 16 of these 22 cases were affected by...

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Detalles Bibliográficos
Autores principales: Petrovay, Fruzsina, Balla, Eszter, Erdősi, Tímea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388118/
https://www.ncbi.nlm.nih.gov/pubmed/28183394
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.5.30455
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author Petrovay, Fruzsina
Balla, Eszter
Erdősi, Tímea
author_facet Petrovay, Fruzsina
Balla, Eszter
Erdősi, Tímea
author_sort Petrovay, Fruzsina
collection PubMed
description In eastern Europe, few countries have so far reported laboratory-confirmed cases of lymphogranuloma venereum (LGV). Here we describe 22 LGV cases in men who have sex with men (MSM) detected in Hungary from November 2012 to July 2016. Sequence analyses show that 16 of these 22 cases were affected by the L2c genovariant, with from 2012 to 2014, one LGV L2c case detected per year, followed by seven cases in 2015 and six up to July 2016. Of the 16 total L2c LGV cases, 10 had severe haemorrhagic proctitis. These findings are concerning as cases with this new genovariant among MSM have not been frequently reported in Europe to date. More research is needed to assess the spread of the L2c genovariant and its potential association with virulence and severe clinical manifestation.
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spelling pubmed-53881182017-04-24 Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016 Petrovay, Fruzsina Balla, Eszter Erdősi, Tímea Euro Surveill Surveillance and Outbreak Report In eastern Europe, few countries have so far reported laboratory-confirmed cases of lymphogranuloma venereum (LGV). Here we describe 22 LGV cases in men who have sex with men (MSM) detected in Hungary from November 2012 to July 2016. Sequence analyses show that 16 of these 22 cases were affected by the L2c genovariant, with from 2012 to 2014, one LGV L2c case detected per year, followed by seven cases in 2015 and six up to July 2016. Of the 16 total L2c LGV cases, 10 had severe haemorrhagic proctitis. These findings are concerning as cases with this new genovariant among MSM have not been frequently reported in Europe to date. More research is needed to assess the spread of the L2c genovariant and its potential association with virulence and severe clinical manifestation. European Centre for Disease Prevention and Control (ECDC) 2017-02-02 /pmc/articles/PMC5388118/ /pubmed/28183394 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.5.30455 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Surveillance and Outbreak Report
Petrovay, Fruzsina
Balla, Eszter
Erdősi, Tímea
Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016
title Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016
title_full Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016
title_fullStr Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016
title_full_unstemmed Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016
title_short Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016
title_sort emergence of the lymphogranuloma venereum l2c genovariant, hungary, 2012 to 2016
topic Surveillance and Outbreak Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388118/
https://www.ncbi.nlm.nih.gov/pubmed/28183394
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.5.30455
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