Interaction between DNA and Drugs Having Protonable Basic Groups: Characterization through Affinity Constants, Drug Release Kinetics, and Conformational Changes

This paper reports the in vitro characterization of the interaction between the phosphate groups of DNA and the protonated species of drugs with basic groups through the determination of the affinity constants, the reversibility of the interaction, and the effect on the secondary structure of the ma...

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Detalles Bibliográficos
Autores principales: Alarcón, Liliana P., Baena, Yolima, Manzo, Rubén H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388140/
https://www.ncbi.nlm.nih.gov/pubmed/28054999
http://dx.doi.org/10.3390/scipharm85010001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388140/
https://www.ncbi.nlm.nih.gov/pubmed/28054999
http://dx.doi.org/10.3390/scipharm85010001

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