Cargando…
Antimutagenic Activity of Ethanol Extract of Rhaphidophora pinnata (L.f) Schott Leaves on Mice
Rhaphidophora pinnata is suggested to prevent or treat cancer of genetic mutations. In this study, antimutagenic activity of an ethanol extract of Rhaphidophora pinnata leaves was evaluated by using a bone marrow micronucleus assay on mice. Male mice (20–30 g) were treated for sevendays with an etha...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388144/ https://www.ncbi.nlm.nih.gov/pubmed/28218683 http://dx.doi.org/10.3390/scipharm85010007 |
_version_ | 1782521079446634496 |
---|---|
author | Masfria, Sumaiyah, Dalimunthe, Aminah |
author_facet | Masfria, Sumaiyah, Dalimunthe, Aminah |
author_sort | Masfria, |
collection | PubMed |
description | Rhaphidophora pinnata is suggested to prevent or treat cancer of genetic mutations. In this study, antimutagenic activity of an ethanol extract of Rhaphidophora pinnata leaves was evaluated by using a bone marrow micronucleus assay on mice. Male mice (20–30 g) were treated for sevendays with an ethanol extract of Rhaphidophora pinnata leaves at a dose of 500, 750 and 1000 mg/kg/day/orally, prior to exposure to cyclophosphamide (i.p. 30 mg/kg), 24 h after the end of the treatment. Antimutagenic activity was determined by the decrease of micronuclei (MN). The results showed that a single administration of all variant doses of the extract had significantly decreased the micronucleus formation in bone marrow cell of mice as compared to the cyclophosphamide group. The ethanol extract of Rhaphidophora pinnata leaves had antimutagenic activity against cyclophosphamide-induced gene mutation. |
format | Online Article Text |
id | pubmed-5388144 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-53881442017-04-14 Antimutagenic Activity of Ethanol Extract of Rhaphidophora pinnata (L.f) Schott Leaves on Mice Masfria, Sumaiyah, Dalimunthe, Aminah Sci Pharm Article Rhaphidophora pinnata is suggested to prevent or treat cancer of genetic mutations. In this study, antimutagenic activity of an ethanol extract of Rhaphidophora pinnata leaves was evaluated by using a bone marrow micronucleus assay on mice. Male mice (20–30 g) were treated for sevendays with an ethanol extract of Rhaphidophora pinnata leaves at a dose of 500, 750 and 1000 mg/kg/day/orally, prior to exposure to cyclophosphamide (i.p. 30 mg/kg), 24 h after the end of the treatment. Antimutagenic activity was determined by the decrease of micronuclei (MN). The results showed that a single administration of all variant doses of the extract had significantly decreased the micronucleus formation in bone marrow cell of mice as compared to the cyclophosphamide group. The ethanol extract of Rhaphidophora pinnata leaves had antimutagenic activity against cyclophosphamide-induced gene mutation. MDPI 2017-02-15 2017 /pmc/articles/PMC5388144/ /pubmed/28218683 http://dx.doi.org/10.3390/scipharm85010007 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Masfria, Sumaiyah, Dalimunthe, Aminah Antimutagenic Activity of Ethanol Extract of Rhaphidophora pinnata (L.f) Schott Leaves on Mice |
title | Antimutagenic Activity of Ethanol Extract of Rhaphidophora pinnata (L.f) Schott Leaves on Mice |
title_full | Antimutagenic Activity of Ethanol Extract of Rhaphidophora pinnata (L.f) Schott Leaves on Mice |
title_fullStr | Antimutagenic Activity of Ethanol Extract of Rhaphidophora pinnata (L.f) Schott Leaves on Mice |
title_full_unstemmed | Antimutagenic Activity of Ethanol Extract of Rhaphidophora pinnata (L.f) Schott Leaves on Mice |
title_short | Antimutagenic Activity of Ethanol Extract of Rhaphidophora pinnata (L.f) Schott Leaves on Mice |
title_sort | antimutagenic activity of ethanol extract of rhaphidophora pinnata (l.f) schott leaves on mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388144/ https://www.ncbi.nlm.nih.gov/pubmed/28218683 http://dx.doi.org/10.3390/scipharm85010007 |
work_keys_str_mv | AT masfria antimutagenicactivityofethanolextractofrhaphidophorapinnatalfschottleavesonmice AT sumaiyah antimutagenicactivityofethanolextractofrhaphidophorapinnatalfschottleavesonmice AT dalimuntheaminah antimutagenicactivityofethanolextractofrhaphidophorapinnatalfschottleavesonmice |