Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice

Whether obesity accelerates or suppresses autophagy in adipose tissue is still debatable. To clarify dysregulation of autophagy and its role in pathologies of obese adipose tissue, we focused on lysosomal function, protease maturation and activity, both in vivo and in vitro. First, we showed that au...

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Detalles Bibliográficos
Autores principales: Mizunoe, Yuhei, Sudo, Yuka, Okita, Naoyuki, Hiraoka, Hidenori, Mikami, Kentaro, Narahara, Tomohiro, Negishi, Arisa, Yoshida, Miki, Higashibata, Rikako, Watanabe, Shukoh, Kaneko, Hiroki, Natori, Daiki, Furuichi, Takuma, Yasukawa, Hiromine, Kobayashi, Masaki, Higami, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Basic Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388215/
https://www.ncbi.nlm.nih.gov/pubmed/28121218
http://dx.doi.org/10.1080/15548627.2016.1274850

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