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Efficacy of the dual PI3K and mTOR inhibitor NVP-BEZ235 in combination with imatinib mesylate against chronic myelogenous leukemia cell lines

BACKGROUND: Phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a therapy target of cancer. We aimed to confirm the effect of dual PI3K/mTOR inhibitor NVP-BEZ235 on proliferation, apoptosis, and autophagy of chronic myelogenous leukemia (CML) cells and sensitiv...

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Detalles Bibliográficos
Autores principales:	Xin, Pengliang, Li, Chuntuan, Zheng, Yan, Peng, Qunyi, Xiao, Huifang, Huang, Yuanling, Zhu, Xiongpeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2017
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388256/ https://www.ncbi.nlm.nih.gov/pubmed/28435223 http://dx.doi.org/10.2147/DDDT.S132092

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