Cytomegalovirus Acquisition and Inflammation in Human Immunodeficiency Virus–Exposed Uninfected Zimbabwean Infants

Cytomegalovirus (CMV) acquisition and inflammation were evaluated in 231 human immunodeficiency virus (HIV)–exposed uninfected (HEU) and 100 HIV-unexposed Zimbabwean infants aged 6 weeks. The HEU and HIV-unexposed infants had a similarly high prevalence of CMV (81.4% vs 74.0%, respectively; P = .14)...

Descripción completa

Detalles Bibliográficos
Autores principales: Evans, Ceri, Chasekwa, Bernard, Rukobo, Sandra, Govha, Margaret, Mutasa, Kuda, Ntozini, Robert, Humphrey, Jean H., Prendergast, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388301/
https://www.ncbi.nlm.nih.gov/pubmed/28011912
http://dx.doi.org/10.1093/infdis/jiw630
_version_ 1782521106521915392
author Evans, Ceri
Chasekwa, Bernard
Rukobo, Sandra
Govha, Margaret
Mutasa, Kuda
Ntozini, Robert
Humphrey, Jean H.
Prendergast, Andrew J.
author_facet Evans, Ceri
Chasekwa, Bernard
Rukobo, Sandra
Govha, Margaret
Mutasa, Kuda
Ntozini, Robert
Humphrey, Jean H.
Prendergast, Andrew J.
author_sort Evans, Ceri
collection PubMed
description Cytomegalovirus (CMV) acquisition and inflammation were evaluated in 231 human immunodeficiency virus (HIV)–exposed uninfected (HEU) and 100 HIV-unexposed Zimbabwean infants aged 6 weeks. The HEU and HIV-unexposed infants had a similarly high prevalence of CMV (81.4% vs 74.0%, respectively; P = .14), but HEU infants had higher CMV loads (P = .005) and >2-fold higher C-reactive protein (CRP) concentrations (P < .0001). The CMV-positive HEU infants had higher CRP than the CMV-negative HEU infants; this association disappeared after adjusting for maternal HIV load. Overall, CMV acquisition is high in early life, but HEU infants have higher CMV loads and a proinflammatory milieu, which may be driven partly by maternal HIV viremia.
format Online
Article
Text
id pubmed-5388301
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-53883012017-04-18 Cytomegalovirus Acquisition and Inflammation in Human Immunodeficiency Virus–Exposed Uninfected Zimbabwean Infants Evans, Ceri Chasekwa, Bernard Rukobo, Sandra Govha, Margaret Mutasa, Kuda Ntozini, Robert Humphrey, Jean H. Prendergast, Andrew J. J Infect Dis Brief Report Cytomegalovirus (CMV) acquisition and inflammation were evaluated in 231 human immunodeficiency virus (HIV)–exposed uninfected (HEU) and 100 HIV-unexposed Zimbabwean infants aged 6 weeks. The HEU and HIV-unexposed infants had a similarly high prevalence of CMV (81.4% vs 74.0%, respectively; P = .14), but HEU infants had higher CMV loads (P = .005) and >2-fold higher C-reactive protein (CRP) concentrations (P < .0001). The CMV-positive HEU infants had higher CRP than the CMV-negative HEU infants; this association disappeared after adjusting for maternal HIV load. Overall, CMV acquisition is high in early life, but HEU infants have higher CMV loads and a proinflammatory milieu, which may be driven partly by maternal HIV viremia. Oxford University Press 2017-03-01 2016-12-23 /pmc/articles/PMC5388301/ /pubmed/28011912 http://dx.doi.org/10.1093/infdis/jiw630 Text en © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Evans, Ceri
Chasekwa, Bernard
Rukobo, Sandra
Govha, Margaret
Mutasa, Kuda
Ntozini, Robert
Humphrey, Jean H.
Prendergast, Andrew J.
Cytomegalovirus Acquisition and Inflammation in Human Immunodeficiency Virus–Exposed Uninfected Zimbabwean Infants
title Cytomegalovirus Acquisition and Inflammation in Human Immunodeficiency Virus–Exposed Uninfected Zimbabwean Infants
title_full Cytomegalovirus Acquisition and Inflammation in Human Immunodeficiency Virus–Exposed Uninfected Zimbabwean Infants
title_fullStr Cytomegalovirus Acquisition and Inflammation in Human Immunodeficiency Virus–Exposed Uninfected Zimbabwean Infants
title_full_unstemmed Cytomegalovirus Acquisition and Inflammation in Human Immunodeficiency Virus–Exposed Uninfected Zimbabwean Infants
title_short Cytomegalovirus Acquisition and Inflammation in Human Immunodeficiency Virus–Exposed Uninfected Zimbabwean Infants
title_sort cytomegalovirus acquisition and inflammation in human immunodeficiency virus–exposed uninfected zimbabwean infants
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388301/
https://www.ncbi.nlm.nih.gov/pubmed/28011912
http://dx.doi.org/10.1093/infdis/jiw630
work_keys_str_mv AT evansceri cytomegalovirusacquisitionandinflammationinhumanimmunodeficiencyvirusexposeduninfectedzimbabweaninfants
AT chasekwabernard cytomegalovirusacquisitionandinflammationinhumanimmunodeficiencyvirusexposeduninfectedzimbabweaninfants
AT rukobosandra cytomegalovirusacquisitionandinflammationinhumanimmunodeficiencyvirusexposeduninfectedzimbabweaninfants
AT govhamargaret cytomegalovirusacquisitionandinflammationinhumanimmunodeficiencyvirusexposeduninfectedzimbabweaninfants
AT mutasakuda cytomegalovirusacquisitionandinflammationinhumanimmunodeficiencyvirusexposeduninfectedzimbabweaninfants
AT ntozinirobert cytomegalovirusacquisitionandinflammationinhumanimmunodeficiencyvirusexposeduninfectedzimbabweaninfants
AT humphreyjeanh cytomegalovirusacquisitionandinflammationinhumanimmunodeficiencyvirusexposeduninfectedzimbabweaninfants
AT prendergastandrewj cytomegalovirusacquisitionandinflammationinhumanimmunodeficiencyvirusexposeduninfectedzimbabweaninfants

Ejemplares similares