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Implantable Systems for Continuous Liquorpheresis and CSF Replacement

Liquorpheresis (cerebrospinal fluid filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators, or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. Continuous or...

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Detalles Bibliográficos
Autor principal: Menéndez González, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388363/
https://www.ncbi.nlm.nih.gov/pubmed/28413734
http://dx.doi.org/10.7759/cureus.1022
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author Menéndez González, Manuel
author_facet Menéndez González, Manuel
author_sort Menéndez González, Manuel
collection PubMed
description Liquorpheresis (cerebrospinal fluid filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators, or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. Continuous or intermittent cerebrospinal fluid (CSF) replacement may be an alternative approach not explored thus far. Here, we review previous experiences in the use of liquorpheresis in autoimmune and degenerative neurological diseases. Then we describe previous technical reports  and provide some new innovations in order to design bidirectional CSF shunting systems that can be complemented either with a deposit of artificial CSF or with a filter of CSF, allowing CSF replacement or liquorpheresis respectively. Both options would lead to mechanical dilution of the patient’s CSF.
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spelling pubmed-53883632017-04-15 Implantable Systems for Continuous Liquorpheresis and CSF Replacement Menéndez González, Manuel Cureus Neurosurgery Liquorpheresis (cerebrospinal fluid filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators, or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. Continuous or intermittent cerebrospinal fluid (CSF) replacement may be an alternative approach not explored thus far. Here, we review previous experiences in the use of liquorpheresis in autoimmune and degenerative neurological diseases. Then we describe previous technical reports  and provide some new innovations in order to design bidirectional CSF shunting systems that can be complemented either with a deposit of artificial CSF or with a filter of CSF, allowing CSF replacement or liquorpheresis respectively. Both options would lead to mechanical dilution of the patient’s CSF. Cureus 2017-02-10 /pmc/articles/PMC5388363/ /pubmed/28413734 http://dx.doi.org/10.7759/cureus.1022 Text en Copyright © 2017, Menéndez González et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurosurgery
Menéndez González, Manuel
Implantable Systems for Continuous Liquorpheresis and CSF Replacement
title Implantable Systems for Continuous Liquorpheresis and CSF Replacement
title_full Implantable Systems for Continuous Liquorpheresis and CSF Replacement
title_fullStr Implantable Systems for Continuous Liquorpheresis and CSF Replacement
title_full_unstemmed Implantable Systems for Continuous Liquorpheresis and CSF Replacement
title_short Implantable Systems for Continuous Liquorpheresis and CSF Replacement
title_sort implantable systems for continuous liquorpheresis and csf replacement
topic Neurosurgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388363/
https://www.ncbi.nlm.nih.gov/pubmed/28413734
http://dx.doi.org/10.7759/cureus.1022
work_keys_str_mv AT menendezgonzalezmanuel implantablesystemsforcontinuousliquorpheresisandcsfreplacement