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Implantable Systems for Continuous Liquorpheresis and CSF Replacement
Liquorpheresis (cerebrospinal fluid filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators, or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. Continuous or...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cureus
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388363/ https://www.ncbi.nlm.nih.gov/pubmed/28413734 http://dx.doi.org/10.7759/cureus.1022 |
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author | Menéndez González, Manuel |
author_facet | Menéndez González, Manuel |
author_sort | Menéndez González, Manuel |
collection | PubMed |
description | Liquorpheresis (cerebrospinal fluid filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators, or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. Continuous or intermittent cerebrospinal fluid (CSF) replacement may be an alternative approach not explored thus far. Here, we review previous experiences in the use of liquorpheresis in autoimmune and degenerative neurological diseases. Then we describe previous technical reports and provide some new innovations in order to design bidirectional CSF shunting systems that can be complemented either with a deposit of artificial CSF or with a filter of CSF, allowing CSF replacement or liquorpheresis respectively. Both options would lead to mechanical dilution of the patient’s CSF. |
format | Online Article Text |
id | pubmed-5388363 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-53883632017-04-15 Implantable Systems for Continuous Liquorpheresis and CSF Replacement Menéndez González, Manuel Cureus Neurosurgery Liquorpheresis (cerebrospinal fluid filtration) comprises a therapeutical approach that has been proposed to treat several neurological conditions where antibodies, inflammatory mediators, or abnormal peptides are the cause or play an important role in the pathogenesis of the disease. Continuous or intermittent cerebrospinal fluid (CSF) replacement may be an alternative approach not explored thus far. Here, we review previous experiences in the use of liquorpheresis in autoimmune and degenerative neurological diseases. Then we describe previous technical reports and provide some new innovations in order to design bidirectional CSF shunting systems that can be complemented either with a deposit of artificial CSF or with a filter of CSF, allowing CSF replacement or liquorpheresis respectively. Both options would lead to mechanical dilution of the patient’s CSF. Cureus 2017-02-10 /pmc/articles/PMC5388363/ /pubmed/28413734 http://dx.doi.org/10.7759/cureus.1022 Text en Copyright © 2017, Menéndez González et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Neurosurgery Menéndez González, Manuel Implantable Systems for Continuous Liquorpheresis and CSF Replacement |
title | Implantable Systems for Continuous Liquorpheresis and CSF Replacement |
title_full | Implantable Systems for Continuous Liquorpheresis and CSF Replacement |
title_fullStr | Implantable Systems for Continuous Liquorpheresis and CSF Replacement |
title_full_unstemmed | Implantable Systems for Continuous Liquorpheresis and CSF Replacement |
title_short | Implantable Systems for Continuous Liquorpheresis and CSF Replacement |
title_sort | implantable systems for continuous liquorpheresis and csf replacement |
topic | Neurosurgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388363/ https://www.ncbi.nlm.nih.gov/pubmed/28413734 http://dx.doi.org/10.7759/cureus.1022 |
work_keys_str_mv | AT menendezgonzalezmanuel implantablesystemsforcontinuousliquorpheresisandcsfreplacement |