Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability

The rules of engagement between zinc finger transcription factors and DNA have been partly defined by in vitro DNA-binding and structural studies, but less is known about how these rules apply in vivo. Here, we demonstrate how a missense mutation in the second zinc finger of Krüppel-like factor-1 (K...

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Detalles Bibliográficos
Autores principales: Gillinder, Kevin R., Ilsley, Melissa D., Nébor, Danitza, Sachidanandam, Ravi, Lajoie, Mathieu, Magor, Graham W., Tallack, Michael R., Bailey, Timothy, Landsberg, Michael J., Mackay, Joel P., Parker, Michael W., Miles, Luke A., Graber, Joel H., Peters, Luanne L., Bieker, James J., Perkins, Andrew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388391/
https://www.ncbi.nlm.nih.gov/pubmed/28180284
http://dx.doi.org/10.1093/nar/gkw1014

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