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Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells

Aberrant formation of interstitial telomeric sequences (ITSs) promotes genome instabilities. However, it is unclear how aberrant ITS formation is suppressed in human cells. Here, we report that MLH1, a key protein involved in mismatch repair (MMR), suppresses telomeric sequence insertion (TSI) at in...

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Detalles Bibliográficos
Autores principales:	Jia, Pingping, Chastain, Megan, Zou, Ying, Her, Chengtao, Chai, Weihang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388398/ https://www.ncbi.nlm.nih.gov/pubmed/28180301 http://dx.doi.org/10.1093/nar/gkw1170

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