Nucleobase modification by an RNA enzyme

Ribozymes can catalyze phosphoryl or nucleotidyl transfer onto ribose hydroxyls of RNA chains. We report a single ribozyme that performs both reactions, with a nucleobase serving as initial acceptor moiety. This unprecedented combined reaction was revealed while investigating potential contributions...

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Detalles Bibliográficos
Autores principales: Poudyal, Raghav R., Nguyen, Phuong D. M., Lokugamage, Melissa P., Callaway, Mackenzie K., Gavette, Jesse V., Krishnamurthy, Ramanarayanan, Burke, Donald H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388400/
https://www.ncbi.nlm.nih.gov/pubmed/28180302
http://dx.doi.org/10.1093/nar/gkw1199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388400/
https://www.ncbi.nlm.nih.gov/pubmed/28180302
http://dx.doi.org/10.1093/nar/gkw1199

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