Competitive regulation of alternative splicing and alternative polyadenylation by hnRNP H and CstF64 determines acetylcholinesterase isoforms

Acetylcholinesterase (AChE), encoded by the ACHE gene, hydrolyzes the neurotransmitter acetylcholine to terminate synaptic transmission. Alternative splicing close to the 3΄ end generates three distinct isoforms of AChE(T), AChE(H) and AChE(R). We found that hnRNP H binds to two specific G-runs in e...

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Detalles Bibliográficos
Autores principales: Nazim, Mohammad, Masuda, Akio, Rahman, Mohammad Alinoor, Nasrin, Farhana, Takeda, Jun-ichi, Ohe, Kenji, Ohkawara, Bisei, Ito, Mikako, Ohno, Kinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388418/
https://www.ncbi.nlm.nih.gov/pubmed/28180311
http://dx.doi.org/10.1093/nar/gkw823

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