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Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses

The RNA interference (RNAi)-based therapeutic ARC-520 for chronic hepatitis B virus (HBV) infection consists of a melittin-derived peptide conjugated to N-acetylgalactosamine for hepatocyte targeting and endosomal escape, and cholesterol-conjugated RNAi triggers, which together result in HBV gene si...

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Detalles Bibliográficos
Autores principales:	Trubetskoy, Vladimir S., Griffin, Jacob B., Nicholas, Anthony L., Nord, Eric M., Xu, Zhao, Peterson, Ryan M., Wooddell, Christine I., Rozema, David B., Wakefield, Darren H., Lewis, David L., Kanner, Steven B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388421/ https://www.ncbi.nlm.nih.gov/pubmed/28180327 http://dx.doi.org/10.1093/nar/gkw828

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