Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity

Aquaglyceroporins (AQPs) transport water and glycerol and play important roles in drug-uptake in pathogenic trypanosomatids. For example, AQP2 in the human-infectious African trypanosome, Trypanosoma brucei gambiense, is responsible for melarsoprol and pentamidine-uptake, and melarsoprol treatment-f...

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Detalles Bibliográficos
Autores principales: Jeacock, Laura, Baker, Nicola, Wiedemar, Natalie, Mäser, Pascal, Horn, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388498/
https://www.ncbi.nlm.nih.gov/pubmed/28358927
http://dx.doi.org/10.1371/journal.ppat.1006307

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