Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance

Although chemotherapy is designed to eradicate tumor cells, it also has significant effects on normal tissues. The platinum-induced fatty acid 16:4(n-3) (hexadeca-4,7,10,13-tetraenoic acid) induces systemic resistance to a broad range of DNA-damaging chemotherapeutics. We show that 16:4(n-3) exerts...

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Detalles Bibliográficos
Autores principales: Houthuijzen, Julia M., Oosterom, Ilse, Hudson, Brian D., Hirasawa, Akira, Daenen, Laura G. M., McLean, Chelsea M., Hansen, Steffen V. F., van Jaarsveld, Marijn T. M., Peeper, Daniel S., Jafari Sadatmand, Sahar, Roodhart, Jeanine M. L., van de Lest, Chris H. A., Ulven, Trond, Ishihara, Kenji, Milligan, Graeme, Voest, Emile E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388545/
https://www.ncbi.nlm.nih.gov/pubmed/28183801
http://dx.doi.org/10.1096/fj.201601248R

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