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Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula

Oesophageal atresia and tracheoesophageal fistula (OA–TOF) are a multifaceted condition which affects patients throughout their lives. Even though it is one of the most common gastrointestinal malformations, most of the current studies focus on gastro-oesophageal reflux disease, anastomotic strictur...

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Autores principales: Duvoisin, Gilles, Krishnan, Usha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388682/
https://www.ncbi.nlm.nih.gov/pubmed/28447027
http://dx.doi.org/10.3389/fped.2017.00076
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author Duvoisin, Gilles
Krishnan, Usha
author_facet Duvoisin, Gilles
Krishnan, Usha
author_sort Duvoisin, Gilles
collection PubMed
description Oesophageal atresia and tracheoesophageal fistula (OA–TOF) are a multifaceted condition which affects patients throughout their lives. Even though it is one of the most common gastrointestinal malformations, most of the current studies focus on gastro-oesophageal reflux disease, anastomotic strictures, and feeding difficulties. However, there is increasing evidence that a proportion of patients with OA–TOF also have abnormal gastric function. This review aims to provide a comprehensive understanding of studies of gastric function in patients with OA–TOF. The etiology of this abnormality has been hypothesized to be congenital and/or acquired. Several modalities are currently available for the investigation of gastric function, each of them trying to answer specific clinical questions. This review summarizes the studies that have looked at gastric function in the OA–TOF cohort with gastric emptying studies (gastric emptying scintigraphy and (13)C octanoic breath test), gastric manometry, electrogastrography, and oral glucose tolerance test. However, these modalities are limited due to poor age-specific normative values and heterogeneous methodologies used. The evaluation of symptoms in this cohort is crucial, modalities for abnormal gastric function are also described. With appropriate investigations and symptoms questionnaires, treatment strategies can be implemented to correct abnormal gastric function and thereby improve the outcomes and quality of life of patients with OA–TOF. This review highlights the need for large international multicentre collaborative studies and high-quality prospective randomized controlled trials to improve our understanding of gastric function in this cohort.
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spelling pubmed-53886822017-04-26 Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula Duvoisin, Gilles Krishnan, Usha Front Pediatr Pediatrics Oesophageal atresia and tracheoesophageal fistula (OA–TOF) are a multifaceted condition which affects patients throughout their lives. Even though it is one of the most common gastrointestinal malformations, most of the current studies focus on gastro-oesophageal reflux disease, anastomotic strictures, and feeding difficulties. However, there is increasing evidence that a proportion of patients with OA–TOF also have abnormal gastric function. This review aims to provide a comprehensive understanding of studies of gastric function in patients with OA–TOF. The etiology of this abnormality has been hypothesized to be congenital and/or acquired. Several modalities are currently available for the investigation of gastric function, each of them trying to answer specific clinical questions. This review summarizes the studies that have looked at gastric function in the OA–TOF cohort with gastric emptying studies (gastric emptying scintigraphy and (13)C octanoic breath test), gastric manometry, electrogastrography, and oral glucose tolerance test. However, these modalities are limited due to poor age-specific normative values and heterogeneous methodologies used. The evaluation of symptoms in this cohort is crucial, modalities for abnormal gastric function are also described. With appropriate investigations and symptoms questionnaires, treatment strategies can be implemented to correct abnormal gastric function and thereby improve the outcomes and quality of life of patients with OA–TOF. This review highlights the need for large international multicentre collaborative studies and high-quality prospective randomized controlled trials to improve our understanding of gastric function in this cohort. Frontiers Media S.A. 2017-04-12 /pmc/articles/PMC5388682/ /pubmed/28447027 http://dx.doi.org/10.3389/fped.2017.00076 Text en Copyright © 2017 Duvoisin and Krishnan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Duvoisin, Gilles
Krishnan, Usha
Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula
title Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula
title_full Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula
title_fullStr Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula
title_full_unstemmed Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula
title_short Gastric Function in Children with Oesophageal Atresia and Tracheoesophageal Fistula
title_sort gastric function in children with oesophageal atresia and tracheoesophageal fistula
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388682/
https://www.ncbi.nlm.nih.gov/pubmed/28447027
http://dx.doi.org/10.3389/fped.2017.00076
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