Toll-Like Receptor 4–Myeloid Differentiation Primary Response Gene 88 Pathway Is Involved in the Inflammatory Development of Polymyositis by Mediating Interferon-γ and Interleukin-17A in Humans and Experimental Autoimmune Myositis Mouse Model

OBJECTIVE: Toll-like receptor 4 (TLR4) is one of the key players in the development of many autoimmune diseases. To determine the possible role of TLR4 in polymyositis (PM) development, we collected muscle samples from PM patients and mice subjected to an experimental autoimmune myositis (EAM) model...

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Detalles Bibliográficos
Autores principales: Zhang, Hongya, He, Fangyuan, Shi, Ming, Wang, Wenxiu, Tian, Xiaojia, Kang, Juan, Han, Wenjuan, Wu, Rui, Zhou, Linfu, Hu, Mengmeng, Li, Xiaobo, Mi, Fang, Zhao, Gang, Jia, Hongge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388689/
https://www.ncbi.nlm.nih.gov/pubmed/28446897
http://dx.doi.org/10.3389/fneur.2017.00132

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