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The Immune Response against Acinetobacter baumannii, an Emerging Pathogen in Nosocomial Infections

Acinetobacter baumannii is the etiologic agent of a wide range of nosocomial infections, including pneumonia, bacteremia, and skin infections. Over the last 45 years, an alarming increase in the antibiotic resistance of this opportunistic microorganism has been reported, a situation that hinders eff...

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Autores principales: García-Patiño, María Guadalupe, García-Contreras, Rodolfo, Licona-Limón, Paula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388700/
https://www.ncbi.nlm.nih.gov/pubmed/28446911
http://dx.doi.org/10.3389/fimmu.2017.00441
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author García-Patiño, María Guadalupe
García-Contreras, Rodolfo
Licona-Limón, Paula
author_facet García-Patiño, María Guadalupe
García-Contreras, Rodolfo
Licona-Limón, Paula
author_sort García-Patiño, María Guadalupe
collection PubMed
description Acinetobacter baumannii is the etiologic agent of a wide range of nosocomial infections, including pneumonia, bacteremia, and skin infections. Over the last 45 years, an alarming increase in the antibiotic resistance of this opportunistic microorganism has been reported, a situation that hinders effective treatments. In order to develop effective therapies against A. baumannii it is crucial to understand the basis of host–bacterium interactions, especially those concerning the immune response of the host. Different innate immune cells such as monocytes, macrophages, dendritic cells, and natural killer cells have been identified as important effectors in the defense against A. baumannii; among them, neutrophils represent a key immune cell indispensable for the control of the infection. Several immune strategies to combat A. baumannii have been identified such as recognition of the bacteria by immune cells through pattern recognition receptors, specifically toll-like receptors, which trigger bactericidal mechanisms including oxidative burst and cytokine and chemokine production to amplify the immune response against the pathogen. However, a complete picture of the protective immune strategies activated by this bacteria and its potential therapeutic use remains to be determined and explored.
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spelling pubmed-53887002017-04-26 The Immune Response against Acinetobacter baumannii, an Emerging Pathogen in Nosocomial Infections García-Patiño, María Guadalupe García-Contreras, Rodolfo Licona-Limón, Paula Front Immunol Immunology Acinetobacter baumannii is the etiologic agent of a wide range of nosocomial infections, including pneumonia, bacteremia, and skin infections. Over the last 45 years, an alarming increase in the antibiotic resistance of this opportunistic microorganism has been reported, a situation that hinders effective treatments. In order to develop effective therapies against A. baumannii it is crucial to understand the basis of host–bacterium interactions, especially those concerning the immune response of the host. Different innate immune cells such as monocytes, macrophages, dendritic cells, and natural killer cells have been identified as important effectors in the defense against A. baumannii; among them, neutrophils represent a key immune cell indispensable for the control of the infection. Several immune strategies to combat A. baumannii have been identified such as recognition of the bacteria by immune cells through pattern recognition receptors, specifically toll-like receptors, which trigger bactericidal mechanisms including oxidative burst and cytokine and chemokine production to amplify the immune response against the pathogen. However, a complete picture of the protective immune strategies activated by this bacteria and its potential therapeutic use remains to be determined and explored. Frontiers Media S.A. 2017-04-12 /pmc/articles/PMC5388700/ /pubmed/28446911 http://dx.doi.org/10.3389/fimmu.2017.00441 Text en Copyright © 2017 García-Patiño, García-Contreras and Licona-Limón https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
García-Patiño, María Guadalupe
García-Contreras, Rodolfo
Licona-Limón, Paula
The Immune Response against Acinetobacter baumannii, an Emerging Pathogen in Nosocomial Infections
title The Immune Response against Acinetobacter baumannii, an Emerging Pathogen in Nosocomial Infections
title_full The Immune Response against Acinetobacter baumannii, an Emerging Pathogen in Nosocomial Infections
title_fullStr The Immune Response against Acinetobacter baumannii, an Emerging Pathogen in Nosocomial Infections
title_full_unstemmed The Immune Response against Acinetobacter baumannii, an Emerging Pathogen in Nosocomial Infections
title_short The Immune Response against Acinetobacter baumannii, an Emerging Pathogen in Nosocomial Infections
title_sort immune response against acinetobacter baumannii, an emerging pathogen in nosocomial infections
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388700/
https://www.ncbi.nlm.nih.gov/pubmed/28446911
http://dx.doi.org/10.3389/fimmu.2017.00441
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