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Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?

In the past years infections caused by multidrug-resistant Gram-negative bacteria have dramatically increased in all parts of the world. This consensus paper is based on presentations, subsequent discussions and an appraisal of current literature by a panel of international experts invited by the Ru...

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Autores principales: Exner, Martin, Bhattacharya, Sanjay, Christiansen, Bärbel, Gebel, Jürgen, Goroncy-Bermes, Peter, Hartemann, Philippe, Heeg, Peter, Ilschner, Carola, Kramer, Axel, Larson, Elaine, Merkens, Wolfgang, Mielke, Martin, Oltmanns, Peter, Ross, Birgit, Rotter, Manfred, Schmithausen, Ricarda Maria, Sonntag, Hans-Günther, Trautmann, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: German Medical Science GMS Publishing House 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388835/
https://www.ncbi.nlm.nih.gov/pubmed/28451516
http://dx.doi.org/10.3205/dgkh000290
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author Exner, Martin
Bhattacharya, Sanjay
Christiansen, Bärbel
Gebel, Jürgen
Goroncy-Bermes, Peter
Hartemann, Philippe
Heeg, Peter
Ilschner, Carola
Kramer, Axel
Larson, Elaine
Merkens, Wolfgang
Mielke, Martin
Oltmanns, Peter
Ross, Birgit
Rotter, Manfred
Schmithausen, Ricarda Maria
Sonntag, Hans-Günther
Trautmann, Matthias
author_facet Exner, Martin
Bhattacharya, Sanjay
Christiansen, Bärbel
Gebel, Jürgen
Goroncy-Bermes, Peter
Hartemann, Philippe
Heeg, Peter
Ilschner, Carola
Kramer, Axel
Larson, Elaine
Merkens, Wolfgang
Mielke, Martin
Oltmanns, Peter
Ross, Birgit
Rotter, Manfred
Schmithausen, Ricarda Maria
Sonntag, Hans-Günther
Trautmann, Matthias
author_sort Exner, Martin
collection PubMed
description In the past years infections caused by multidrug-resistant Gram-negative bacteria have dramatically increased in all parts of the world. This consensus paper is based on presentations, subsequent discussions and an appraisal of current literature by a panel of international experts invited by the Rudolf Schülke Stiftung, Hamburg. It deals with the epidemiology and the inherent properties of Gram-negative bacteria, elucidating the patterns of the spread of antibiotic resistance, highlighting reservoirs as well as transmission pathways and risk factors for infection, mortality, treatment and prevention options as well as the consequences of their prevalence in livestock. Following a global, One Health approach and based on the evaluation of the existing knowledge about these pathogens, this paper gives recommendations for prevention and infection control measures as well as proposals for various target groups to tackle the threats posed by Gram-negative bacteria and prevent the spread and emergence of new antibiotic resistances.
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spelling pubmed-53888352017-04-27 Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria? Exner, Martin Bhattacharya, Sanjay Christiansen, Bärbel Gebel, Jürgen Goroncy-Bermes, Peter Hartemann, Philippe Heeg, Peter Ilschner, Carola Kramer, Axel Larson, Elaine Merkens, Wolfgang Mielke, Martin Oltmanns, Peter Ross, Birgit Rotter, Manfred Schmithausen, Ricarda Maria Sonntag, Hans-Günther Trautmann, Matthias GMS Hyg Infect Control Article In the past years infections caused by multidrug-resistant Gram-negative bacteria have dramatically increased in all parts of the world. This consensus paper is based on presentations, subsequent discussions and an appraisal of current literature by a panel of international experts invited by the Rudolf Schülke Stiftung, Hamburg. It deals with the epidemiology and the inherent properties of Gram-negative bacteria, elucidating the patterns of the spread of antibiotic resistance, highlighting reservoirs as well as transmission pathways and risk factors for infection, mortality, treatment and prevention options as well as the consequences of their prevalence in livestock. Following a global, One Health approach and based on the evaluation of the existing knowledge about these pathogens, this paper gives recommendations for prevention and infection control measures as well as proposals for various target groups to tackle the threats posed by Gram-negative bacteria and prevent the spread and emergence of new antibiotic resistances. German Medical Science GMS Publishing House 2017-04-10 /pmc/articles/PMC5388835/ /pubmed/28451516 http://dx.doi.org/10.3205/dgkh000290 Text en Copyright © 2017 Exner et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. See license information at http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Exner, Martin
Bhattacharya, Sanjay
Christiansen, Bärbel
Gebel, Jürgen
Goroncy-Bermes, Peter
Hartemann, Philippe
Heeg, Peter
Ilschner, Carola
Kramer, Axel
Larson, Elaine
Merkens, Wolfgang
Mielke, Martin
Oltmanns, Peter
Ross, Birgit
Rotter, Manfred
Schmithausen, Ricarda Maria
Sonntag, Hans-Günther
Trautmann, Matthias
Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?
title Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?
title_full Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?
title_fullStr Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?
title_full_unstemmed Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?
title_short Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?
title_sort antibiotic resistance: what is so special about multidrug-resistant gram-negative bacteria?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388835/
https://www.ncbi.nlm.nih.gov/pubmed/28451516
http://dx.doi.org/10.3205/dgkh000290
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