Mutations in PMR1 stimulate xylose isomerase activity and anaerobic growth on xylose of engineered Saccharomyces cerevisiae by influencing manganese homeostasis

Combined overexpression of xylulokinase, pentose-phosphate-pathway enzymes and a heterologous xylose isomerase (XI) is required but insufficient for anaerobic growth of Saccharomyces cerevisiae on d-xylose. Single-step Cas9-assisted implementation of these modifications yielded a yeast strain expres...

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Detalles Bibliográficos
Autores principales: Verhoeven, Maarten D., Lee, Misun, Kamoen, Lycka, van den Broek, Marcel, Janssen, Dick B., Daran, Jean-Marc G., van Maris, Antonius J. A., Pronk, Jack T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388867/
https://www.ncbi.nlm.nih.gov/pubmed/28401919
http://dx.doi.org/10.1038/srep46155

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