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A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor

Lycorine potently inhibits flaviviruses in cell culture. At 1.2-μM concentration, lycorine reduced viral titers of West Nile (WNV), dengue, and yellow fever viruses by 10(2)- to 10(4)-fold. However, the compound did not inhibit an alphavirus (Western equine encephalitis virus) or a rhabdovirus (vesi...

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Detalles Bibliográficos
Autores principales:	Zou, Gang, Puig-Basagoiti, Francesc, Zhang, Bo, Qing, Min, Chen, Liqiang, Pankiewicz, Krzysztof W., Felczak, Krzysztof, Yuan, Zhiming, Shi, Pei-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388927/ https://www.ncbi.nlm.nih.gov/pubmed/19062063 http://dx.doi.org/10.1016/j.virol.2008.11.003

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