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Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar

BACKGROUND: Human mammary tumor virus (HMTV) is 90–95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors. HMTV (MMTV-like) sequences were reported to be present in human breast cancers from several populations with a prevalence range of 0–78%; however,...

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Autores principales: San, Thar Htet, Fujisawa, Masayoshi, Fushimi, Soichiro, Yoshimura, Teizo, Ohara, Toshiaki, Soe, Lamin, Min, Ngu Wah, Kyaw, Ohnmar, Yang, Xu, Matsukawa, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389013/
https://www.ncbi.nlm.nih.gov/pubmed/28413435
http://dx.doi.org/10.1186/s13027-017-0130-0
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author San, Thar Htet
Fujisawa, Masayoshi
Fushimi, Soichiro
Yoshimura, Teizo
Ohara, Toshiaki
Soe, Lamin
Min, Ngu Wah
Kyaw, Ohnmar
Yang, Xu
Matsukawa, Akihiro
author_facet San, Thar Htet
Fujisawa, Masayoshi
Fushimi, Soichiro
Yoshimura, Teizo
Ohara, Toshiaki
Soe, Lamin
Min, Ngu Wah
Kyaw, Ohnmar
Yang, Xu
Matsukawa, Akihiro
author_sort San, Thar Htet
collection PubMed
description BACKGROUND: Human mammary tumor virus (HMTV) is 90–95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors. HMTV (MMTV-like) sequences were reported to be present in human breast cancers from several populations with a prevalence range of 0–78%; however, the prevalence of HMTV in breast cancers from Myanmar remains unknown. METHODS: Fifty-eight breast cancer samples from Myanmar women were examined in this study. DNA was isolated from formalin-fixed paraffin-embedded specimens, and HMTV envelope sequences were detected by semi-nested PCR. The sequence of the PCR products was also confirmed. RESULTS: Only 1.7% (1 of 58) of the breast cancers were positive for HMTV, and the sequence of PCR products was 98.9% identical to the reference HMTV sequence (GenBank accession No. AF243039). The tumor with HMTV was grade III invasive ductal carcinoma, 7.0 cm in size with lymph node metastasis (T3, N1, M0). CONCLUSIONS: We, for the first time, investigated the presence of HMTV in Myanmar breast cancer patients. In accordance with other Asian studies, the prevalence of HMTV in Myanmar was quite low, supporting the hypothesis that Asian breast cancers have different etiologies than in Western countries, where HMTV is more prevalent.
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spelling pubmed-53890132017-04-14 Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar San, Thar Htet Fujisawa, Masayoshi Fushimi, Soichiro Yoshimura, Teizo Ohara, Toshiaki Soe, Lamin Min, Ngu Wah Kyaw, Ohnmar Yang, Xu Matsukawa, Akihiro Infect Agent Cancer Research Article BACKGROUND: Human mammary tumor virus (HMTV) is 90–95% homologous to mouse mammary tumor virus (MMTV), one of the causal agents of murine mammary tumors. HMTV (MMTV-like) sequences were reported to be present in human breast cancers from several populations with a prevalence range of 0–78%; however, the prevalence of HMTV in breast cancers from Myanmar remains unknown. METHODS: Fifty-eight breast cancer samples from Myanmar women were examined in this study. DNA was isolated from formalin-fixed paraffin-embedded specimens, and HMTV envelope sequences were detected by semi-nested PCR. The sequence of the PCR products was also confirmed. RESULTS: Only 1.7% (1 of 58) of the breast cancers were positive for HMTV, and the sequence of PCR products was 98.9% identical to the reference HMTV sequence (GenBank accession No. AF243039). The tumor with HMTV was grade III invasive ductal carcinoma, 7.0 cm in size with lymph node metastasis (T3, N1, M0). CONCLUSIONS: We, for the first time, investigated the presence of HMTV in Myanmar breast cancer patients. In accordance with other Asian studies, the prevalence of HMTV in Myanmar was quite low, supporting the hypothesis that Asian breast cancers have different etiologies than in Western countries, where HMTV is more prevalent. BioMed Central 2017-04-12 /pmc/articles/PMC5389013/ /pubmed/28413435 http://dx.doi.org/10.1186/s13027-017-0130-0 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
San, Thar Htet
Fujisawa, Masayoshi
Fushimi, Soichiro
Yoshimura, Teizo
Ohara, Toshiaki
Soe, Lamin
Min, Ngu Wah
Kyaw, Ohnmar
Yang, Xu
Matsukawa, Akihiro
Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar
title Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar
title_full Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar
title_fullStr Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar
title_full_unstemmed Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar
title_short Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar
title_sort low prevalence of human mammary tumor virus (hmtv) in breast cancer patients from myanmar
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389013/
https://www.ncbi.nlm.nih.gov/pubmed/28413435
http://dx.doi.org/10.1186/s13027-017-0130-0
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