MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects

We investigated miR21 expression in omental (OAT) and subcutaneous adipose tissue (SAT) from 16 obese subjects undergoing bariatric surgery. Patients were divided into two age- and BMI-matched groups according to the presence of type 2 diabetes (T2D). miR21 was not differently expressed in OAT and S...

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Detalles Bibliográficos
Autores principales: Guglielmi, Valeria, D’Adamo, Monica, Menghini, Rossella, Cardellini, Marina, Gentileschi, Paolo, Federici, Massimo, Sbraccia, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389040/
https://www.ncbi.nlm.nih.gov/pubmed/28447068
http://dx.doi.org/10.3233/NHA-160020
Descripción
Sumario:We investigated miR21 expression in omental (OAT) and subcutaneous adipose tissue (SAT) from 16 obese subjects undergoing bariatric surgery. Patients were divided into two age- and BMI-matched groups according to the presence of type 2 diabetes (T2D). miR21 was not differently expressed in OAT and SAT. However, miR21 expression was two folds greater in adipose tissue in patients with T2D. Accordingly, in primary cultures of adipocytes from non diabetic overweight subjects, miR21 expression increased after 24-h exposure to high glucose and insulin. In conclusion, miR21 appears linked to insulin-resistance deterioration within its pathophysiologic progression from obesity to T2D.

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