MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects

We investigated miR21 expression in omental (OAT) and subcutaneous adipose tissue (SAT) from 16 obese subjects undergoing bariatric surgery. Patients were divided into two age- and BMI-matched groups according to the presence of type 2 diabetes (T2D). miR21 was not differently expressed in OAT and S...

Descripción completa

Detalles Bibliográficos
Autores principales: Guglielmi, Valeria, D’Adamo, Monica, Menghini, Rossella, Cardellini, Marina, Gentileschi, Paolo, Federici, Massimo, Sbraccia, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389040/
https://www.ncbi.nlm.nih.gov/pubmed/28447068
http://dx.doi.org/10.3233/NHA-160020
_version_ 1782521217368981504
author Guglielmi, Valeria
D’Adamo, Monica
Menghini, Rossella
Cardellini, Marina
Gentileschi, Paolo
Federici, Massimo
Sbraccia, Paolo
author_facet Guglielmi, Valeria
D’Adamo, Monica
Menghini, Rossella
Cardellini, Marina
Gentileschi, Paolo
Federici, Massimo
Sbraccia, Paolo
author_sort Guglielmi, Valeria
collection PubMed
description We investigated miR21 expression in omental (OAT) and subcutaneous adipose tissue (SAT) from 16 obese subjects undergoing bariatric surgery. Patients were divided into two age- and BMI-matched groups according to the presence of type 2 diabetes (T2D). miR21 was not differently expressed in OAT and SAT. However, miR21 expression was two folds greater in adipose tissue in patients with T2D. Accordingly, in primary cultures of adipocytes from non diabetic overweight subjects, miR21 expression increased after 24-h exposure to high glucose and insulin. In conclusion, miR21 appears linked to insulin-resistance deterioration within its pathophysiologic progression from obesity to T2D.
format Online
Article
Text
id pubmed-5389040
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher IOS Press
record_format MEDLINE/PubMed
spelling pubmed-53890402017-04-24 MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects Guglielmi, Valeria D’Adamo, Monica Menghini, Rossella Cardellini, Marina Gentileschi, Paolo Federici, Massimo Sbraccia, Paolo Nutr Healthy Aging Brief Communication We investigated miR21 expression in omental (OAT) and subcutaneous adipose tissue (SAT) from 16 obese subjects undergoing bariatric surgery. Patients were divided into two age- and BMI-matched groups according to the presence of type 2 diabetes (T2D). miR21 was not differently expressed in OAT and SAT. However, miR21 expression was two folds greater in adipose tissue in patients with T2D. Accordingly, in primary cultures of adipocytes from non diabetic overweight subjects, miR21 expression increased after 24-h exposure to high glucose and insulin. In conclusion, miR21 appears linked to insulin-resistance deterioration within its pathophysiologic progression from obesity to T2D. IOS Press 2017-03-31 /pmc/articles/PMC5389040/ /pubmed/28447068 http://dx.doi.org/10.3233/NHA-160020 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Guglielmi, Valeria
D’Adamo, Monica
Menghini, Rossella
Cardellini, Marina
Gentileschi, Paolo
Federici, Massimo
Sbraccia, Paolo
MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects
title MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects
title_full MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects
title_fullStr MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects
title_full_unstemmed MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects
title_short MicroRNA 21 is up-regulated in adipose tissue of obese diabetic subjects
title_sort microrna 21 is up-regulated in adipose tissue of obese diabetic subjects
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389040/
https://www.ncbi.nlm.nih.gov/pubmed/28447068
http://dx.doi.org/10.3233/NHA-160020
work_keys_str_mv AT guglielmivaleria microrna21isupregulatedinadiposetissueofobesediabeticsubjects
AT dadamomonica microrna21isupregulatedinadiposetissueofobesediabeticsubjects
AT menghinirossella microrna21isupregulatedinadiposetissueofobesediabeticsubjects
AT cardellinimarina microrna21isupregulatedinadiposetissueofobesediabeticsubjects
AT gentileschipaolo microrna21isupregulatedinadiposetissueofobesediabeticsubjects
AT federicimassimo microrna21isupregulatedinadiposetissueofobesediabeticsubjects
AT sbracciapaolo microrna21isupregulatedinadiposetissueofobesediabeticsubjects

Ejemplares similares