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Screening for Mild Cognitive Impairment and Dementia with Automated, Anonymous Online and Telephone Cognitive Self-Tests

Background: Many older people worry about cognitive decline. Early cognitive screening in an anonymous and easily accessible manner may reassure older people who are unnecessarily worried about normal cognitive aging while it may also expedite help seeking in case of suspicious cognitive decline. Ob...

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Autores principales: Van Mierlo, Lisa D., Wouters, Hans, Sikkes, Sietske A.M., Van der Flier, Wiesje M., Prins, Niels D., Bremer, Jonne A.E., Koene, Teddy, Van Hout, Hein P.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389042/
https://www.ncbi.nlm.nih.gov/pubmed/27911296
http://dx.doi.org/10.3233/JAD-160566
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author Van Mierlo, Lisa D.
Wouters, Hans
Sikkes, Sietske A.M.
Van der Flier, Wiesje M.
Prins, Niels D.
Bremer, Jonne A.E.
Koene, Teddy
Van Hout, Hein P.J.
author_facet Van Mierlo, Lisa D.
Wouters, Hans
Sikkes, Sietske A.M.
Van der Flier, Wiesje M.
Prins, Niels D.
Bremer, Jonne A.E.
Koene, Teddy
Van Hout, Hein P.J.
author_sort Van Mierlo, Lisa D.
collection PubMed
description Background: Many older people worry about cognitive decline. Early cognitive screening in an anonymous and easily accessible manner may reassure older people who are unnecessarily worried about normal cognitive aging while it may also expedite help seeking in case of suspicious cognitive decline. Objective: To develop and validate online and telephone-based automated self-tests of cognitive function. Methods: We examined the feasibility and validity of the self-tests in a prospective study of 117 participants of whom 34 had subjective cognitive decline (SCD), 30 had mild cognitive impairment (MCI), and 53 had dementia. The ability of these self-tests to accurately distinguish MCI and dementia from SCD was examined with ROC curves. Convergent validity was examined by calculating rank correlations between the self-tests and neuropsychological tests. Results: Both the online and telephone cognitive self-tests were feasible, because the majority of participants (86% and 80%, respectively) were able to complete them. The online self-test had adequate diagnostic accuracy in the screening for MCI and dementia versus SCD with an Area under the Curve (AUC) of 0.86 (95% CI: 0.78–0.93). The AUC of the MMSE was 0.82 (95% CI: 0.74–0.89). By contrast, the telephone self-test had lower diagnostic accuracy (AUC = 0.75, 95% CI: 0.64–0.86). Both self-tests had good convergent validity as demonstrated by moderate to strong rank correlations with neuropsychological tests. Conclusion: We demonstrated good diagnostic accuracy and convergent validity for the online self-test of cognitive function. It is therefore a promising tool in the screening for MCI and dementia.
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spelling pubmed-53890422017-04-24 Screening for Mild Cognitive Impairment and Dementia with Automated, Anonymous Online and Telephone Cognitive Self-Tests Van Mierlo, Lisa D. Wouters, Hans Sikkes, Sietske A.M. Van der Flier, Wiesje M. Prins, Niels D. Bremer, Jonne A.E. Koene, Teddy Van Hout, Hein P.J. J Alzheimers Dis Research Article Background: Many older people worry about cognitive decline. Early cognitive screening in an anonymous and easily accessible manner may reassure older people who are unnecessarily worried about normal cognitive aging while it may also expedite help seeking in case of suspicious cognitive decline. Objective: To develop and validate online and telephone-based automated self-tests of cognitive function. Methods: We examined the feasibility and validity of the self-tests in a prospective study of 117 participants of whom 34 had subjective cognitive decline (SCD), 30 had mild cognitive impairment (MCI), and 53 had dementia. The ability of these self-tests to accurately distinguish MCI and dementia from SCD was examined with ROC curves. Convergent validity was examined by calculating rank correlations between the self-tests and neuropsychological tests. Results: Both the online and telephone cognitive self-tests were feasible, because the majority of participants (86% and 80%, respectively) were able to complete them. The online self-test had adequate diagnostic accuracy in the screening for MCI and dementia versus SCD with an Area under the Curve (AUC) of 0.86 (95% CI: 0.78–0.93). The AUC of the MMSE was 0.82 (95% CI: 0.74–0.89). By contrast, the telephone self-test had lower diagnostic accuracy (AUC = 0.75, 95% CI: 0.64–0.86). Both self-tests had good convergent validity as demonstrated by moderate to strong rank correlations with neuropsychological tests. Conclusion: We demonstrated good diagnostic accuracy and convergent validity for the online self-test of cognitive function. It is therefore a promising tool in the screening for MCI and dementia. IOS Press 2017-01-12 /pmc/articles/PMC5389042/ /pubmed/27911296 http://dx.doi.org/10.3233/JAD-160566 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Van Mierlo, Lisa D.
Wouters, Hans
Sikkes, Sietske A.M.
Van der Flier, Wiesje M.
Prins, Niels D.
Bremer, Jonne A.E.
Koene, Teddy
Van Hout, Hein P.J.
Screening for Mild Cognitive Impairment and Dementia with Automated, Anonymous Online and Telephone Cognitive Self-Tests
title Screening for Mild Cognitive Impairment and Dementia with Automated, Anonymous Online and Telephone Cognitive Self-Tests
title_full Screening for Mild Cognitive Impairment and Dementia with Automated, Anonymous Online and Telephone Cognitive Self-Tests
title_fullStr Screening for Mild Cognitive Impairment and Dementia with Automated, Anonymous Online and Telephone Cognitive Self-Tests
title_full_unstemmed Screening for Mild Cognitive Impairment and Dementia with Automated, Anonymous Online and Telephone Cognitive Self-Tests
title_short Screening for Mild Cognitive Impairment and Dementia with Automated, Anonymous Online and Telephone Cognitive Self-Tests
title_sort screening for mild cognitive impairment and dementia with automated, anonymous online and telephone cognitive self-tests
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389042/
https://www.ncbi.nlm.nih.gov/pubmed/27911296
http://dx.doi.org/10.3233/JAD-160566
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