Sugammadex to reverse neuromuscular blockade and provide optimal conditions for motor-evoked potential monitoring

Sugammadex is a novel pharmacologic agent, which reverses neuromuscular blockade (NMB) via a mechanism that differs completely from acetylcholinesterase inhibitors. By encapsulating rocuronium, sugammadex can provide recovery of neuromuscular function even when there is a profound degree of NMB. We...

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Autores principales: Trifa, Mehdi, Krishna, Senthil, D’Mello, Ajay, Hakim, Mumin, Tobias, Joseph Drew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389243/
https://www.ncbi.nlm.nih.gov/pubmed/28442963
http://dx.doi.org/10.4103/1658-354X.203024
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author Trifa, Mehdi
Krishna, Senthil
D’Mello, Ajay
Hakim, Mumin
Tobias, Joseph Drew
author_facet Trifa, Mehdi
Krishna, Senthil
D’Mello, Ajay
Hakim, Mumin
Tobias, Joseph Drew
author_sort Trifa, Mehdi
collection PubMed
description Sugammadex is a novel pharmacologic agent, which reverses neuromuscular blockade (NMB) via a mechanism that differs completely from acetylcholinesterase inhibitors. By encapsulating rocuronium, sugammadex can provide recovery of neuromuscular function even when there is a profound degree of NMB. We report anecdotal experience with the use of sugammadex to reverse NMB to facilitate intraoperative neurophysiological monitoring (motor evoked potentials) in an adolescent with scoliosis during posterior spinal fusion. Its potential application in this unique clinical scenario is discussed, and potential dosing schemes are reviewed.
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spelling pubmed-53892432017-04-25 Sugammadex to reverse neuromuscular blockade and provide optimal conditions for motor-evoked potential monitoring Trifa, Mehdi Krishna, Senthil D’Mello, Ajay Hakim, Mumin Tobias, Joseph Drew Saudi J Anaesth Case Report Sugammadex is a novel pharmacologic agent, which reverses neuromuscular blockade (NMB) via a mechanism that differs completely from acetylcholinesterase inhibitors. By encapsulating rocuronium, sugammadex can provide recovery of neuromuscular function even when there is a profound degree of NMB. We report anecdotal experience with the use of sugammadex to reverse NMB to facilitate intraoperative neurophysiological monitoring (motor evoked potentials) in an adolescent with scoliosis during posterior spinal fusion. Its potential application in this unique clinical scenario is discussed, and potential dosing schemes are reviewed. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5389243/ /pubmed/28442963 http://dx.doi.org/10.4103/1658-354X.203024 Text en Copyright: © 2017 Saudi Journal of Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Trifa, Mehdi
Krishna, Senthil
D’Mello, Ajay
Hakim, Mumin
Tobias, Joseph Drew
Sugammadex to reverse neuromuscular blockade and provide optimal conditions for motor-evoked potential monitoring
title Sugammadex to reverse neuromuscular blockade and provide optimal conditions for motor-evoked potential monitoring
title_full Sugammadex to reverse neuromuscular blockade and provide optimal conditions for motor-evoked potential monitoring
title_fullStr Sugammadex to reverse neuromuscular blockade and provide optimal conditions for motor-evoked potential monitoring
title_full_unstemmed Sugammadex to reverse neuromuscular blockade and provide optimal conditions for motor-evoked potential monitoring
title_short Sugammadex to reverse neuromuscular blockade and provide optimal conditions for motor-evoked potential monitoring
title_sort sugammadex to reverse neuromuscular blockade and provide optimal conditions for motor-evoked potential monitoring
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389243/
https://www.ncbi.nlm.nih.gov/pubmed/28442963
http://dx.doi.org/10.4103/1658-354X.203024
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