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Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer’s disease-like tau pathology

Abnormally hyperphosphorylated tau aggregated as intraneuronal neurofibrillary tangles is one of the two neuropathological hallmarks of Alzheimer’s disease (AD). The majority of AD cases are sporadic with numerous environmental, biological and genetic risks factors. Interestingly, insulin dysfunctio...

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Detalles Bibliográficos
Autores principales:	Gratuze, Maud, Julien, Jacinthe, Petry, Franck R., Morin, Françoise, Planel, Emmanuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389355/ https://www.ncbi.nlm.nih.gov/pubmed/28402338 http://dx.doi.org/10.1038/srep46359

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