Ageing in the musculoskeletal system: Cellular function and dysfunction throughout life

The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, and together they contribute to pain and loss of mob...

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Detalles Bibliográficos
Autores principales: Roberts, Sally, Colombier, Pauline, Sowman, Aneka, Mennan, Claire, Rölfing, Jan H D, Guicheux, Jérôme, Edwards, James R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389428/
https://www.ncbi.nlm.nih.gov/pubmed/27748151
http://dx.doi.org/10.1080/17453674.2016.1244750
Descripción
Sumario:The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, and together they contribute to pain and loss of mobility. This review covers the cellular constituents that make up some key components of the musculoskeletal system and summarizes discussion from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS) (Regeneration in the Ageing Population) about how each particular cell type alters within the ageing skeletal microenvironment.

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