Ageing in the musculoskeletal system: Cellular function and dysfunction throughout life

The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, and together they contribute to pain and loss of mob...

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Detalles Bibliográficos
Autores principales: Roberts, Sally, Colombier, Pauline, Sowman, Aneka, Mennan, Claire, Rölfing, Jan H D, Guicheux, Jérôme, Edwards, James R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389428/
https://www.ncbi.nlm.nih.gov/pubmed/27748151
http://dx.doi.org/10.1080/17453674.2016.1244750
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author Roberts, Sally
Colombier, Pauline
Sowman, Aneka
Mennan, Claire
Rölfing, Jan H D
Guicheux, Jérôme
Edwards, James R
author_facet Roberts, Sally
Colombier, Pauline
Sowman, Aneka
Mennan, Claire
Rölfing, Jan H D
Guicheux, Jérôme
Edwards, James R
author_sort Roberts, Sally
collection PubMed
description The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, and together they contribute to pain and loss of mobility. This review covers the cellular constituents that make up some key components of the musculoskeletal system and summarizes discussion from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS) (Regeneration in the Ageing Population) about how each particular cell type alters within the ageing skeletal microenvironment.
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spelling pubmed-53894282017-04-17 Ageing in the musculoskeletal system: Cellular function and dysfunction throughout life Roberts, Sally Colombier, Pauline Sowman, Aneka Mennan, Claire Rölfing, Jan H D Guicheux, Jérôme Edwards, James R Acta Orthop Articles The extent of ageing in the musculoskeletal system during the life course affects the quality and length of life. Loss of bone, degraded articular cartilage, and degenerate, narrowed intervertebral discs are primary features of an ageing skeleton, and together they contribute to pain and loss of mobility. This review covers the cellular constituents that make up some key components of the musculoskeletal system and summarizes discussion from the 2015 Aarhus Regenerative Orthopaedic Symposium (AROS) (Regeneration in the Ageing Population) about how each particular cell type alters within the ageing skeletal microenvironment. Taylor & Francis 2016-12 2016-10-17 /pmc/articles/PMC5389428/ /pubmed/27748151 http://dx.doi.org/10.1080/17453674.2016.1244750 Text en © 2016 The Author(s). Published by Taylor & Francis on behalf of the Nordic Orthopedic Federation. https://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/3.0)
spellingShingle Articles
Roberts, Sally
Colombier, Pauline
Sowman, Aneka
Mennan, Claire
Rölfing, Jan H D
Guicheux, Jérôme
Edwards, James R
Ageing in the musculoskeletal system: Cellular function and dysfunction throughout life
title Ageing in the musculoskeletal system: Cellular function and dysfunction throughout life
title_full Ageing in the musculoskeletal system: Cellular function and dysfunction throughout life
title_fullStr Ageing in the musculoskeletal system: Cellular function and dysfunction throughout life
title_full_unstemmed Ageing in the musculoskeletal system: Cellular function and dysfunction throughout life
title_short Ageing in the musculoskeletal system: Cellular function and dysfunction throughout life
title_sort ageing in the musculoskeletal system: cellular function and dysfunction throughout life
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389428/
https://www.ncbi.nlm.nih.gov/pubmed/27748151
http://dx.doi.org/10.1080/17453674.2016.1244750
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