Role of the chromatin landscape and sequence in determining cell type-specific genomic glucocorticoid receptor binding and gene regulation

The genomic loci bound by the glucocorticoid receptor (GR), a hormone-activated transcription factor, show little overlap between cell types. To study the role of chromatin and sequence in specifying where GR binds, we used Bayesian modeling within the universe of accessible chromatin. Taken togethe...

Descripción completa

Detalles Bibliográficos
Autores principales: Love, Michael I., Huska, Matthew R., Jurk, Marcel, Schöpflin, Robert, Starick, Stephan R., Schwahn, Kevin, Cooper, Samantha B., Yamamoto, Keith R., Thomas-Chollier, Morgane, Vingron, Martin, Meijsing, Sebastiaan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389550/
https://www.ncbi.nlm.nih.gov/pubmed/27903902
http://dx.doi.org/10.1093/nar/gkw1163

Ejemplares similares

Ejemplares similares