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PATZ1 down-regulates FADS1 by binding to rs174557 and is opposed by SP1/SREBP1c
The FADS1 and FADS2 genes in the FADS cluster encode the rate-limiting enzymes in the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs). Genetic variation in this region has been associated with a large number of diseases and traits many of them correlated to differences in metabolism o...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389558/ https://www.ncbi.nlm.nih.gov/pubmed/27932482 http://dx.doi.org/10.1093/nar/gkw1186 |