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Stoichiometries of U2AF35, U2AF65 and U2 snRNP reveal new early spliceosome assembly pathways

The selection of 3΄ splice sites (3΄ss) is an essential early step in mammalian RNA splicing reactions, but the processes involved are unknown. We have used single molecule methods to test whether the major components implicated in selection, the proteins U2AF35 and U2AF65 and the U2 snRNP, are able...

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Detalles Bibliográficos
Autores principales:	Chen, Li, Weinmeister, Robert, Kralovicova, Jana, Eperon, Lucy P., Vorechovsky, Igor, Hudson, Andrew J., Eperon, Ian C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389562/ https://www.ncbi.nlm.nih.gov/pubmed/27683217 http://dx.doi.org/10.1093/nar/gkw860

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