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Cdc45-induced loading of human RPA onto single-stranded DNA

Cell division cycle protein 45 (Cdc45) is an essential component of the eukaryotic replicative DNA helicase. We found that human Cdc45 forms a complex with the single-stranded DNA (ssDNA) binding protein RPA. Moreover, it actively loads RPA onto nascent ssDNA. Pull-down assays and surface plasmon re...

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Detalles Bibliográficos
Autores principales:	Szambowska, Anna, Tessmer, Ingrid, Prus, Piotr, Schlott, Bernhard, Pospiech, Helmut, Grosse, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389570/ https://www.ncbi.nlm.nih.gov/pubmed/28100698 http://dx.doi.org/10.1093/nar/gkw1364

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