FACT is a sensor of DNA torsional stress in eukaryotic cells

Transitions of B-DNA to alternative DNA structures (ADS) can be triggered by negative torsional strain, which occurs during replication and transcription, and may lead to genomic instability. However, how ADS are recognized in cells is unclear. We found that the binding of candidate anticancer drug,...

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Detalles Bibliográficos
Autores principales: Safina, Alfiya, Cheney, Peter, Pal, Mahadeb, Brodsky, Leonid, Ivanov, Alexander, Kirsanov, Kirill, Lesovaya, Ekaterina, Naberezhnov, Denis, Nesher, Elimelech, Koman, Igor, Wang, Dan, Wang, Jianming, Yakubovskaya, Marianna, Winkler, Duane, Gurova, Katerina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389579/
https://www.ncbi.nlm.nih.gov/pubmed/28082391
http://dx.doi.org/10.1093/nar/gkw1366

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