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A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N(4)-ethenocytosine

Etheno (ε) DNA base adducts are highly mutagenic lesions produced endogenously via reactions with lipid peroxidation (LPO) products. Cancer-promoting conditions, such as inflammation, can induce persistent oxidative stress and increased LPO, resulting in the accumulation of ε-adducts in different ti...

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Detalles Bibliográficos
Autores principales:	Chaim, Isaac A., Gardner, Alycia, Wu, Jie, Iyama, Teruaki, Wilson, David M., Samson, Leona D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389632/ https://www.ncbi.nlm.nih.gov/pubmed/28115629 http://dx.doi.org/10.1093/nar/gkx015

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