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Destabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylase

The base excision repair (BER) pathway repairs oxidized lesions in the DNA that result from reactive oxygen species generated in cells. If left unrepaired, these damaged DNA bases can disrupt cellular processes such as replication. NEIL1 is one of the 11 human DNA glycosylases that catalyze the firs...

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Detalles Bibliográficos
Autores principales:	Prakash, Aishwarya, Moharana, Kedar, Wallace, Susan S., Doublié, Sylvie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389659/ https://www.ncbi.nlm.nih.gov/pubmed/27994037 http://dx.doi.org/10.1093/nar/gkw1282

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