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DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA

Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes. Hybrid substrates are deaminated efficiently by ADAR deaminase domains at dA-C mismatches a...

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Detalles Bibliográficos
Autores principales:	Zheng, Yuxuan, Lorenzo, Claire, Beal, Peter A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389660/ https://www.ncbi.nlm.nih.gov/pubmed/28132026 http://dx.doi.org/10.1093/nar/gkx050

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