Cargando…
Toxin inhibition in C. crescentus VapBC1 is mediated by a flexible pseudo-palindromic protein motif and modulated by DNA binding
Expression of bacterial type II toxin-antitoxin (TA) systems is regulated at the transcriptional level through direct binding of the antitoxin to pseudo-palindromic sequences on operator DNA. In this context, the toxin functions as a co-repressor by stimulating DNA binding through direct interaction...
Autores principales: | Bendtsen, Kirstine L., Xu, Kehan, Luckmann, Majbritt, Winther, Kristoffer S., Shah, Shiraz A., Pedersen, Christian N. S., Brodersen, Ditlev E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389673/ https://www.ncbi.nlm.nih.gov/pubmed/27998932 http://dx.doi.org/10.1093/nar/gkw1266 |
Ejemplares similares
-
Regulation of Enteric vapBC Transcription: Induction by VapC Toxin Dimer-Breaking
por: Winther, Kristoffer S., et al.
Publicado: (2012) -
Crystal Structure of the VapBC Toxin–Antitoxin Complex from Shigella flexneri Reveals a Hetero-Octameric DNA-Binding Assembly
por: Dienemann, Christian, et al.
Publicado: (2011) -
Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis
por: Maté, María J., et al.
Publicado: (2012) -
Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides
por: Lee, In-Gyun, et al.
Publicado: (2015) -
Functional details of the Mycobacterium tuberculosis VapBC26 toxin-antitoxin system based on a structural study: insights into unique binding and antibiotic peptides
por: Kang, Sung-Min, et al.
Publicado: (2017)