SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage

Telomere repeat binding factor 2 (TRF2) has been increasingly recognized to be involved in telomere maintenance and DNA damage response. Here, we show that TRF2 directly binds SIRT6 in a DNA independent manner and that this interaction is increased upon replication stress. Knockdown of SIRT6 up-regu...

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Detalles Bibliográficos
Autores principales: Rizzo, Angela, Iachettini, Sara, Salvati, Erica, Zizza, Pasquale, Maresca, Carmen, D'Angelo, Carmen, Benarroch-Popivker, Delphine, Capolupo, Angela, del Gaudio, Federica, Cosconati, Sandro, Di Maro, Salvatore, Merlino, Francesco, Novellino, Ettore, Amoreo, Carla Azzurra, Mottolese, Marcella, Sperduti, Isabella, Gilson, Eric, Biroccio, Annamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389694/
https://www.ncbi.nlm.nih.gov/pubmed/27923994
http://dx.doi.org/10.1093/nar/gkw1202

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