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Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands

Alternative lengthening of telomeres (ALT) is a telomerase independent telomere maintenance mechanism that occurs in ∼15% of cancers. The potential mechanism of ALT is homology-directed telomere synthesis, but molecular mechanisms of how ALT maintains telomere length in human cancer is poorly unders...

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Detalles Bibliográficos
Autores principales:	Min, Jaewon, Wright, Woodring E., Shay, Jerry W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389697/ https://www.ncbi.nlm.nih.gov/pubmed/28082393 http://dx.doi.org/10.1093/nar/gkw1295

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