Temporal association of ORCA/LRWD1 to late-firing origins during G1 dictates heterochromatin replication and organization

DNA replication requires the recruitment of a pre-replication complex facilitated by Origin Recognition Complex (ORC) onto the chromatin during G1 phase of the cell cycle. The ORC-associated protein (ORCA/LRWD1) stabilizes ORC on chromatin. Here, we evaluated the genome-wide distribution of ORCA usi...

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Detalles Bibliográficos
Autores principales: Wang, Yating, Khan, Abid, Marks, Anna B., Smith, Owen K., Giri, Sumanprava, Lin, Yo-Chuen, Creager, Rachel, MacAlpine, David M., Prasanth, Kannanganattu V., Aladjem, Mirit I., Prasanth, Supriya G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389698/
https://www.ncbi.nlm.nih.gov/pubmed/27924004
http://dx.doi.org/10.1093/nar/gkw1211

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