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Inhibiting translation elongation can aid genome duplication in Escherichia coli

Conflicts between replication and transcription challenge chromosome duplication. Escherichia coli replisome movement along transcribed DNA is promoted by Rep and UvrD accessory helicases with Δrep ΔuvrD cells being inviable under rapid growth conditions. We have discovered that mutations in a tRNA...

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Detalles Bibliográficos
Autores principales:	Myka, Kamila K., Hawkins, Michelle, Syeda, Aisha H., Gupta, Milind K., Meharg, Caroline, Dillingham, Mark S., Savery, Nigel J., Lloyd, Robert G., McGlynn, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389703/ https://www.ncbi.nlm.nih.gov/pubmed/27956500 http://dx.doi.org/10.1093/nar/gkw1254

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