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Empower multiplex cell and tissue-specific CRISPR-mediated gene manipulation with self-cleaving ribozymes and tRNA

Clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9) system has emerged in recent years as a highly efficient RNA-guided gene manipulation platform. Simultaneous editing or transcriptional activation/suppression of different genes becomes feasible with the co-delivery of multi...

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Detalles Bibliográficos
Autores principales:	Xu, Li, Zhao, Lixia, Gao, Yandi, Xu, Jing, Han, Renzhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389707/ https://www.ncbi.nlm.nih.gov/pubmed/27799472 http://dx.doi.org/10.1093/nar/gkw1048

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