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Folate deficiency facilitates recruitment of upstream binding factor to hot spots of DNA double-strand breaks of rRNA genes and promotes its transcription

The biogenesis of ribosomes in vivo is an essential process for cellular functions. Transcription of ribosomal RNA (rRNA) genes is the rate-limiting step in ribosome biogenesis controlled by environmental conditions. Here, we investigated the role of folate antagonist on changes of DNA double-strand...

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Detalles Bibliográficos
Autores principales:	Xie, Qiu, Li, Caihua, Song, Xiaozhen, Wu, Lihua, Jiang, Qian, Qiu, Zhiyong, Cao, Haiyan, Yu, Kaihui, Wan, Chunlei, Li, Jianting, Yang, Feng, Huang, Zebing, niu, Bo, Jiang, Zhengwen, Zhang, Ting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2017
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389733/ https://www.ncbi.nlm.nih.gov/pubmed/27924000 http://dx.doi.org/10.1093/nar/gkw1208

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