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Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains

γ-Secretase cleavage of the Notch receptor transmembrane domain is a critical signaling event for various cellular processes. Efforts to develop inhibitors of γ-secretase cleavage of the amyloid-β precursor C99 protein as potential Alzheimer’s disease therapeutics have been confounded by toxicity re...

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Detalles Bibliográficos
Autores principales:	Deatherage, Catherine L., Lu, Zhenwei, Kroncke, Brett M., Ma, Sirui, Smith, Jarrod A., Voehler, Markus W., McFeeters, Robert L., Sanders, Charles R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389784/ https://www.ncbi.nlm.nih.gov/pubmed/28439555 http://dx.doi.org/10.1126/sciadv.1602794

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