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Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites

Obesity is a complex multifactorial phenotype that influences several metabolic pathways. Yet, few studies have examined the relations of different body fat compartments to urinary and serum metabolites. Anthropometric phenotypes (visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), the...

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Autores principales: Schlecht, Inga, Gronwald, Wolfram, Behrens, Gundula, Baumeister, Sebastian E., Hertel, Johannes, Hochrein, Jochen, Zacharias, Helena U., Fischer, Beate, Oefner, Peter J., Leitzmann, Michael F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389790/
https://www.ncbi.nlm.nih.gov/pubmed/28403191
http://dx.doi.org/10.1371/journal.pone.0175133
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author Schlecht, Inga
Gronwald, Wolfram
Behrens, Gundula
Baumeister, Sebastian E.
Hertel, Johannes
Hochrein, Jochen
Zacharias, Helena U.
Fischer, Beate
Oefner, Peter J.
Leitzmann, Michael F.
author_facet Schlecht, Inga
Gronwald, Wolfram
Behrens, Gundula
Baumeister, Sebastian E.
Hertel, Johannes
Hochrein, Jochen
Zacharias, Helena U.
Fischer, Beate
Oefner, Peter J.
Leitzmann, Michael F.
author_sort Schlecht, Inga
collection PubMed
description Obesity is a complex multifactorial phenotype that influences several metabolic pathways. Yet, few studies have examined the relations of different body fat compartments to urinary and serum metabolites. Anthropometric phenotypes (visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), the ratio between VAT and SAT (VSR), body mass index (BMI), waist circumference (WC)) and urinary and serum metabolite concentrations measured by nuclear magnetic resonance spectroscopy were measured in a population-based sample of 228 healthy adults. Multivariable linear and logistic regression models, corrected for multiple testing using the false discovery rate, were used to associate anthropometric phenotypes with metabolites. We adjusted for potential confounding variables: age, sex, smoking, physical activity, menopausal status, estimated glomerular filtration rate (eGFR), urinary glucose, and fasting status. In a fully adjusted logistic regression model dichotomized for the absence or presence of quantifiable metabolite amounts, VAT, BMI and WC were inversely related to urinary choline (ß = -0.18, p = 2.73*10(−3)), glycolic acid (ß = -0.20, 0.02), and guanidinoacetic acid (ß = -0.12, p = 0.04), and positively related to ethanolamine (ß = 0.18, p = 0.02) and dimethylamine (ß = 0.32, p = 0.02). BMI and WC were additionally inversely related to urinary glutamine and lactic acid. Moreover, WC was inversely associated with the detection of serine. VAT, but none of the other anthropometric parameters, was related to serum essential amino acids, such as valine, isoleucine, and phenylalanine among men. Compared to other adiposity measures, VAT demonstrated the strongest and most significant relations to urinary and serum metabolites. The distinct relations of VAT, SAT, VSR, BMI, and WC to metabolites emphasize the importance of accurately differentiating between body fat compartments when evaluating the potential role of metabolic regulation in the development of obesity-related diseases, such as insulin resistance, type 2 diabetes, and cardiovascular disease.
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spelling pubmed-53897902017-05-03 Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites Schlecht, Inga Gronwald, Wolfram Behrens, Gundula Baumeister, Sebastian E. Hertel, Johannes Hochrein, Jochen Zacharias, Helena U. Fischer, Beate Oefner, Peter J. Leitzmann, Michael F. PLoS One Research Article Obesity is a complex multifactorial phenotype that influences several metabolic pathways. Yet, few studies have examined the relations of different body fat compartments to urinary and serum metabolites. Anthropometric phenotypes (visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), the ratio between VAT and SAT (VSR), body mass index (BMI), waist circumference (WC)) and urinary and serum metabolite concentrations measured by nuclear magnetic resonance spectroscopy were measured in a population-based sample of 228 healthy adults. Multivariable linear and logistic regression models, corrected for multiple testing using the false discovery rate, were used to associate anthropometric phenotypes with metabolites. We adjusted for potential confounding variables: age, sex, smoking, physical activity, menopausal status, estimated glomerular filtration rate (eGFR), urinary glucose, and fasting status. In a fully adjusted logistic regression model dichotomized for the absence or presence of quantifiable metabolite amounts, VAT, BMI and WC were inversely related to urinary choline (ß = -0.18, p = 2.73*10(−3)), glycolic acid (ß = -0.20, 0.02), and guanidinoacetic acid (ß = -0.12, p = 0.04), and positively related to ethanolamine (ß = 0.18, p = 0.02) and dimethylamine (ß = 0.32, p = 0.02). BMI and WC were additionally inversely related to urinary glutamine and lactic acid. Moreover, WC was inversely associated with the detection of serine. VAT, but none of the other anthropometric parameters, was related to serum essential amino acids, such as valine, isoleucine, and phenylalanine among men. Compared to other adiposity measures, VAT demonstrated the strongest and most significant relations to urinary and serum metabolites. The distinct relations of VAT, SAT, VSR, BMI, and WC to metabolites emphasize the importance of accurately differentiating between body fat compartments when evaluating the potential role of metabolic regulation in the development of obesity-related diseases, such as insulin resistance, type 2 diabetes, and cardiovascular disease. Public Library of Science 2017-04-12 /pmc/articles/PMC5389790/ /pubmed/28403191 http://dx.doi.org/10.1371/journal.pone.0175133 Text en © 2017 Schlecht et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Schlecht, Inga
Gronwald, Wolfram
Behrens, Gundula
Baumeister, Sebastian E.
Hertel, Johannes
Hochrein, Jochen
Zacharias, Helena U.
Fischer, Beate
Oefner, Peter J.
Leitzmann, Michael F.
Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites
title Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites
title_full Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites
title_fullStr Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites
title_full_unstemmed Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites
title_short Visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites
title_sort visceral adipose tissue but not subcutaneous adipose tissue is associated with urine and serum metabolites
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389790/
https://www.ncbi.nlm.nih.gov/pubmed/28403191
http://dx.doi.org/10.1371/journal.pone.0175133
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